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The Apomorphine Test in Parkinsonian Syndromes JNNP 54:870-872, D'Costa,D.F.,et al, 1991 See this aricle in Pubmed Article Abstract The dopamine receptor agonist apomorphine has been used successfully to treat on-off swings in Parkinson's disease.Its value as a predictor of dopa responsiveness in idiopathic Parkinson's disease(IPD)was assessed and its potential role in differentiating IPD from the Parkinsonism plus syndrome s(PPS)of multisystem atrophy,progressive supranuclear palsy and olivopontocerebellar atrophy was investigated.The response to an injection of apomorphine was observed in 20 patients with IPD and eight with PPS after being off levodopa for 12 hours.Patients were reassessed after taking levodopa for one month.Nineteen of the 20 patients(95%)with IPD showed a positive response to apomorphine and 18(90%)to oral levodopa.In the PPS group,two patients(25%)responded to the apomorphine injection but not to oral levodopa.Apomorphine produced severe drowsiness in the PPS patients.It is suggested that the test can predict dopa responsiveness in IPD and may be of help in confirming a doubtful diagnosis.It has potential value in differentiating IPD from PPS.

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(click to filter results - removes previous filter) apomorphine dopamine agonist Parkinson disease Parkinson disease,differential diagnosis of Parkinson disease,treatment of progressive supranuclear palsy

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